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Inhibition of HIV-1 Replication by a Bis-Thiadiazolbenzene-1,2-Diamine That Chelates Zinc Ions from Retroviral Nucleocapsid Zinc Fingers

The human immunodeficiency virus type 1 (HIV-1) nucleocapsid p7 (NCp7) protein holds two highly conserved “CCHC” zinc finger domains that are required for several phases of viral replication. Basic residues flank the zinc fingers, and both determinants are required for high-affinity binding to RNA....

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書誌詳細
主要な著者: Pannecouque, Christophe, Szafarowicz, Beata, Volkova, Natalia, Bakulev, Vasiliy, Dehaen, Wim, Mély, Yves, Daelemans, Dirk
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849360/
https://ncbi.nlm.nih.gov/pubmed/20124006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01671-09
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