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The In Vivo Mechanism of Action of CTLA4Ig

A single dose of CTLA4Ig, an inhibitor of CD28-mediated T cell costimulation, given 2 days after transplantation induces specific unresponsiveness to alloantigens in vivo. However, the mechanisms responsible are unknown. Using pigeon cytochrome c as a model Ag, we monitored the effect of CTLA4Ig on...

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Autors principals: Judge, Thomas A., Tang, Aimin, Spain, Lisa M., Gratiot-Deans, Jeanne, Sayegh, Mohamed H., Turka, Laurence A.
Format: Artigo
Idioma:Inglês
Publicat: 1996
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849296/
https://ncbi.nlm.nih.gov/pubmed/8690920
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