Structure–Activity Relationships in Cholapod Anion Carriers: Enhanced Transmembrane Chloride Transport through Substituent Tuning

Chloride transport by a series of steroid-based “cholapod” receptors/carriers was studied in vesicles. The principal method involved preincorporation of the cholapods in the vesicle membranes, and the use of lucigenin fluorescence quenching to detect inward-transported Cl(−). The results showed a pa...

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Main Authors: McNally, Beth A., Koulov, Atanas V., Lambert, Timothy N., Smith, Bradley D., Joos, Jean-Baptiste, Sisson, Adam L., Clare, John P., Sgarlata, Valentina, Judd, Luke W., Magro, Germinal, Davis, Anthony P.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849112/
https://ncbi.nlm.nih.gov/pubmed/18773409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.200801163
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