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Identification of Hypermethylated Genes Associated with Cisplatin Resistance in Human Cancers

Cisplatin is among the most widely used cytotoxic anti-cancer agents in solid tumors, however, the development of secondary resistance remains a major obstacle to clinical efficacy. Treatment-related DNA hypermethylation may play a role in creating drug resistant phenotypes by inactivating genes tha...

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Bibliografiske detaljer
Main Authors: Chang, Xiaofei, Monitto, Constance L., Demokan, Semra, Kim, Myoung Sook, Chang, Steven S., Zhong, Xiaoli, Califano, Joseph A., Sidransky, David
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849007/
https://ncbi.nlm.nih.gov/pubmed/20215521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3427
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