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Binding of GTPγ[(35)S] is regulated by GDP and receptor activation. Studies with the nociceptin/orphanin FQ receptor
BACKGROUND AND PURPOSE: We have examined the effects of ligand efficacy and receptor density on the binding of guanosine 5′-[γ-thio]triphosphate (GTPγS) and GDP to the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP)-coupled G-proteins. EXPERIMENTAL APPROACH: In GTPγ[(35)S] binding experiments,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2848932/ https://ncbi.nlm.nih.gov/pubmed/20148892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00621.x |
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