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Diet-Induced Obesity Alters Vincristine Pharmacokinetics in Blood and Tissues of Mice

Obesity is associated with poorer outcome from many cancers, including leukemia. One possible contributor to this could be suboptimal chemotherapy dosing in obese patients. We have previously found that vincristine (VCR) is less effective in obese compared to non-obese mice with leukemia, despite we...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Behan, James W., Avramis, Vassilios I., Yun, Jason P., Louie, Stan G., Mittelman, Steven D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848885/
https://ncbi.nlm.nih.gov/pubmed/20083201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2010.01.007
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