Virulent Toxoplasma gondii Evade Immunity-Related GTPase (IRG)-Mediated Parasite Vacuole Disruption Within Primed Macrophages

Cytokine-activated macrophages restrain the replication of intracellular parasites and disrupt the integrity of vacuolar pathogens. Here we show that NOS2 and the IRG family member Irgm3, respectively are required for the ability of in vivo primed macrophages to restrain the growth of Toxoplasma gon...

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Main Authors: Zhao, Yanlin, Ferguson, David J. P., Wilson, Douglas C., Howard, Jonathan C., Sibley, L. David, Yap, George S.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848815/
https://ncbi.nlm.nih.gov/pubmed/19265156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804190
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