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Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation

The tumor suppressor p53 functions as a transcriptional activator for many genes, including several key genes involved in cell cycle arrest and apoptosis. Following DNA damage-induced stress, p53 undergoes extensive post-translational modification, resulting in increased stability and activity. Two...

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Библиографические подробности
Главные авторы: Miller Jenkins, Lisa M., Yamaguchi, Hiroshi, Hayashi, Ryo, Cherry, Scott, Tropea, Joseph E., Miller, Maria, Wlodawer, Alexander, Appella, Ettore, Mazur, Sharlyn J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848171/
https://ncbi.nlm.nih.gov/pubmed/19166313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801716h
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