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The NPIY motif in the integrin β1 tail dictates the requirement for talin-1 in outside-in signaling

Protein interactions with the integrin β-subunit cytoplasmic domain (β-tail) are essential for adhesion-dependent processes, including cell spreading and the connection of integrins with actin filaments at adhesion sites. Talin-1 binds to the conserved membrane-proximal NPxY motif of β-tails (NPIY i...

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Detalles Bibliográficos
Main Authors: Nieves, Bethsaida, Jones, Christopher W., Ward, Rachel, Ohta, Yasutaka, Reverte, Carlos G., LaFlamme, Susan E.
Formato: Artigo
Idioma:Inglês
Publicado: Company of Biologists 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848110/
https://ncbi.nlm.nih.gov/pubmed/20332112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.056549
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