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The NPIY motif in the integrin β1 tail dictates the requirement for talin-1 in outside-in signaling
Protein interactions with the integrin β-subunit cytoplasmic domain (β-tail) are essential for adhesion-dependent processes, including cell spreading and the connection of integrins with actin filaments at adhesion sites. Talin-1 binds to the conserved membrane-proximal NPxY motif of β-tails (NPIY i...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Company of Biologists
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2848110/ https://ncbi.nlm.nih.gov/pubmed/20332112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.056549 |
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