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Darwinian Evolution of Prions in Cell Culture
Prions are infectious proteins consisting mainly of PrP(Sc), a β sheet-rich conformer of the normal host protein PrP(C), and occur in different strains. Strain identity is thought to be encoded by PrP(Sc) conformation. We found that biologically cloned prion populations gradually became heterogeneou...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2848070/ https://ncbi.nlm.nih.gov/pubmed/20044542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1183218 |
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