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Two Phases of Actin Polymerization Display Different Dependencies on PI(3,4,5)P(3) Accumulation and Have Unique Roles during Chemotaxis

The directional movement of cells in chemoattractant gradients requires sophisticated control of the actin cytoskeleton. Uniform exposure of Dictyostelium discoideum amoebae as well as mammalian leukocytes to chemoattractant triggers two phases of actin polymerization. In the initial rapid phase, mo...

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Udgivet i:Mol Biol Cell
Principais autores: Chen, Lingfeng, Janetopoulos, Chris, Huang, Yi Elaine, Iijima, Miho, Borleis, Jane, Devreotes, Peter N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2003
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284804/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14595116/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-05-0339
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