Cytosolic group IVa phospholipase A(2 )mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro

BACKGROUND: Cytosolic gIVaPLA(2 )is a critical enzyme in the generation of arachidonate metabolites and in induction of β(2)-integrin adhesion in granulocytes. We hypothesized that gIVaPLA(2 )activation also is an essential downstream step for post adhesive migration of PMN in vitro. METHODS: Migrat...

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Autors principals: Meliton, Angelo Y, Muñoz, Nilda M, Meliton, Lucille N, Binder, David C, Osan, Christopher M, Zhu, Xiangdong, Dudek, Steven M, Leff, Alan R
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848033/
https://ncbi.nlm.nih.gov/pubmed/20298597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-7-14
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