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TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN
Upon recognition of influenza virus (Flu) via TLR7, plasmacytoid dendritic cells (pDCs) produce type I IFN in significant amounts. Synthetic TLR7 ligands induce the maturation of pDCs, as evidenced by the expression of costimulatory molecules and the production of pro-inflammatory cytokines; however...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847942/ https://ncbi.nlm.nih.gov/pubmed/19553637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-216770 |
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