The MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells

Recent studies have reported that the crosslinking of regulatory receptors (RRs), such as blood dendritic cell antigen 2 (BDCA-2) (CD303) or ILT7 (CD85g), of plasmacytoid dendritic cells (pDCs) efficiently suppresses the production of type I interferons (IFN-I, α/β/ω) and other cytokines in response...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Janovec, Vaclav, Aouar, Besma, Font-Haro, Albert, Hofman, Tomas, Trejbalova, Katerina, Weber, Jan, Chaperot, Laurence, Plumas, Joel, Olive, Daniel, Dubreuil, Patrice, Nunès, Jacques A., Stranska, Ruzena, Hirsch, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835309/
https://ncbi.nlm.nih.gov/pubmed/29535732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00364
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