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β-secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins

The amyloid precursor family of proteins are of considerable interest both because of their role in Alzheimer’s disease pathogenesis and because of their normal physiological functions. In mammals, the amyloid precursor protein (APP) has two homologs, amyloid precursor-like protein 1 and amyloid pre...

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Detalhes bibliográficos
Main Authors: Frigerio, Carlo Sala, Fadeeva, Julia V., Minogue, Aedín M., Citron, Martin, Leuven, Fred Van, Stufenbiel, Matthias, Paganetti, Paolo, Selkoe, Dennis J., Walsh, Dominic M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847843/
https://ncbi.nlm.nih.gov/pubmed/20163459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2010.07579.x
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