Pigment Epithelium-Derived Factor Stimulates Tumor Macrophage Recruitment and Is Downregulated by the Prostate Tumor Microenvironment

Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis but whether it has additional effects on the tumor microenvironment is largely unexplored. We show that overexpression of PEDF in orthotopic MatLyLu rat prostate tumors increased tumor macrophage recruitment. The fraction...

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Hlavní autoři: Halin, Sofia, Stina Häggström, Rudolfsson, Doll, Jennifer A, Crawford, Susan E, Wikström, Pernilla, Bergh, Anders
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847741/
https://ncbi.nlm.nih.gov/pubmed/20360944
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