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Pigment Epithelium-Derived Factor Stimulates Tumor Macrophage Recruitment and Is Downregulated by the Prostate Tumor Microenvironment

Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis but whether it has additional effects on the tumor microenvironment is largely unexplored. We show that overexpression of PEDF in orthotopic MatLyLu rat prostate tumors increased tumor macrophage recruitment. The fraction...

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Detalhes bibliográficos
Main Authors: Halin, Sofia, Stina Häggström, Rudolfsson, Doll, Jennifer A, Crawford, Susan E, Wikström, Pernilla, Bergh, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847741/
https://ncbi.nlm.nih.gov/pubmed/20360944
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