Pigment Epithelium-Derived Factor Stimulates Tumor Macrophage Recruitment and Is Downregulated by the Prostate Tumor Microenvironment

Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis but whether it has additional effects on the tumor microenvironment is largely unexplored. We show that overexpression of PEDF in orthotopic MatLyLu rat prostate tumors increased tumor macrophage recruitment. The fraction...

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Bibliographic Details
Main Authors: Halin, Sofia, Stina Häggström, Rudolfsson, Doll, Jennifer A, Crawford, Susan E, Wikström, Pernilla, Bergh, Anders
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847741/
https://ncbi.nlm.nih.gov/pubmed/20360944
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