Small Molecule Inhibitors of Wnt/β-Catenin/Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells In Vitro and In Vivo

BACKGROUND: Lymphoid enhancer factor-1 (lef-1) is overexpressed in B-cell chronic lymphocytic leukemia (CLL) when compared with normal B cells and transcribes several genes implicated in the pathogenesis of CLL. We therefore hypothesize that antagonism of lef-1 might lead to killing of CLL cells. We...

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Main Authors: Gandhirajan, Rajesh Kumar, Staib, Peter Anton, Minke, Katharina, Gehrke, Iris, Plickert, Günther, Schlösser, Axel, Schmitt, Esther Katharina, Hallek, Michael, Kreuzer, Karl-Anton
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847740/
https://ncbi.nlm.nih.gov/pubmed/20360943
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