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Mechanism and Specificity of DNA Strand Exchange Catalyzed by Vaccinia DNA Topoisomerase Type I
The type I DNA topoisomerase from vaccinia virus (vTopo) forms a reversible covalent 3′-phosphotyrosyl linkage with a single strand of duplex DNA at the preferred sequence 5′-(C/T)CCTTp↓N(−1)N(−2)N(−3)-3′. The enzyme-DNA covalent adduct is recombinogenic in cells, because the nicked strand downstrea...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847668/ https://ncbi.nlm.nih.gov/pubmed/20187656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902204v |
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