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Unmasking Anticooperative DNA Binding Interactions of Vaccinia DNA Topoisomerase I
Vaccinia DNA topoisomerase (vTopo) catalyzes highly specific nucleophilic substitution at a single phosphodiester linkage in the pentapyrimidine recognition sequence 5′- (C/T)(+5)C(+4)C(+3)T(+2)T(+1)p↓N(−1) using an active site tyrosine nucleophile, thereby expelling a 5′ hydroxyl leaving group of t...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2528075/ https://ncbi.nlm.nih.gov/pubmed/17198389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061706u |
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