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Major Groove Interactions of Vaccinia Topo I Provide Specificity by Optimally Positioning the Covalent Phosphotyrosine Linkage

Vaccinia DNA topoisomerase (vTopo) is a prototypic eukaryotic type I topoisomerase that shows high specificity for nucleophilic substitution at a single phosphodiester linkage in the pentapyrimidine recognition sequence 5′-(C/T)(+5)C(+4)C(+3)T(+2)T(+1)p↓N(-1). This reaction involves reversible trans...

詳細記述

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書誌詳細
主要な著者: Nagarajan, Rajesh, Stivers, James T.
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515098/
https://ncbi.nlm.nih.gov/pubmed/16669621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060133i
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