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Major Groove Interactions of Vaccinia Topo I Provide Specificity by Optimally Positioning the Covalent Phosphotyrosine Linkage
Vaccinia DNA topoisomerase (vTopo) is a prototypic eukaryotic type I topoisomerase that shows high specificity for nucleophilic substitution at a single phosphodiester linkage in the pentapyrimidine recognition sequence 5′-(C/T)(+5)C(+4)C(+3)T(+2)T(+1)p↓N(-1). This reaction involves reversible trans...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2515098/ https://ncbi.nlm.nih.gov/pubmed/16669621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060133i |
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