Comparison of rates of intracellular metabolism of zidovudine in human and primate peripheral blood mononuclear cells.

3'-Azido-3'-deoxythymidine (AZT) is a drug of choice for the treatment of AIDS. On the basis of pharmacokinetic data, the nonhuman primate Macaca nemestrina has been shown to be a suitable animal model for use in the study of the disposition of AZT. However, since AZT is activated to its metabolite,...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Qian, M, Chandrasena, G, Ho, R J, Unadkat, J D
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1994
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284751/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7840577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.10.2398
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