Development of a New Cartridge Radioimmunoassay for Determination of Intracellular Levels of Lamivudine Triphosphate in the Peripheral Blood Mononuclear Cells of Human Immunodeficiency Virus-Infected Patients

A new sensitive method for the measurement of lamivudine triphosphate (3TC-TP), the active intracellular metabolite of lamivudine in human cells in vivo, has been established. The procedure involves rapid separation of 3TC-TP by using Sep-Pak cartridges, dephosphorylation to 3TC by using acid phosph...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Robbins, Brian L., Tran, Thu T., Pinkerton, Frank H., Akeb, Fatima, Guedj, Roger, Grassi, Jacques, Lancaster, Danny, Fridland, Arnold
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Pharmacology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105914/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9756772/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.10.2656
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