Development of a New Cartridge Radioimmunoassay for Determination of Intracellular Levels of Lamivudine Triphosphate in the Peripheral Blood Mononuclear Cells of Human Immunodeficiency Virus-Infected Patients

A new sensitive method for the measurement of lamivudine triphosphate (3TC-TP), the active intracellular metabolite of lamivudine in human cells in vivo, has been established. The procedure involves rapid separation of 3TC-TP by using Sep-Pak cartridges, dephosphorylation to 3TC by using acid phosph...

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Bibliographische Detailangaben
Hauptverfasser: Robbins, Brian L., Tran, Thu T., Pinkerton, Frank H., Akeb, Fatima, Guedj, Roger, Grassi, Jacques, Lancaster, Danny, Fridland, Arnold
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1998
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC105914/
https://ncbi.nlm.nih.gov/pubmed/9756772
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