Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs.

(-)-beta-L-2',3'-Dideoxycytidine (L-ddC) and (-)-beta-L-2',3'-dideoxy-5-fluorocytidine (L-FddC) have been reported to be potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) in vitro. In the present study, the 5'-triphosphates of L-ddC (L-ddCTP) and L-Fdd...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Faraj, A, Agrofoglio, L A, Wakefield, J K, McPherson, S, Morrow, C D, Gosselin, G, Mathe, C, Imbach, J L, Schinazi, R F, Sommadossi, J P
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1994
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7530932/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.10.2300
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