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Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs.

(-)-beta-L-2',3'-Dideoxycytidine (L-ddC) and (-)-beta-L-2',3'-dideoxy-5-fluorocytidine (L-FddC) have been reported to be potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) in vitro. In the present study, the 5'-triphosphates of L-ddC (L-ddCTP) and L-Fdd...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Faraj, A, Agrofoglio, L A, Wakefield, J K, McPherson, S, Morrow, C D, Gosselin, G, Mathe, C, Imbach, J L, Schinazi, R F, Sommadossi, J P
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284734/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7530932/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.10.2300
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