A Dynamic Model of HIV Integrase Inhibition and Drug Resistance

Human immunodeficiency virus type 1 (HIV-1) integrase is one of three virally encoded enzymes essential for replication and, therefore, a rational choice as a drug target for the treatment of HIV-1 infected individuals. In 2007 raltegravir became the first integrase inhibitor approved for use in the...

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Hlavní autoři: Perryman, Alex L., Forli, Stefano, Morris, Garrett M., Burt, Catherine, Cheng, Yuhui, Palmer, Michael J., Whitby, Kevin, McCammon, J. Andrew, Phillips, Chris, Olson, Arthur J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846753/
https://ncbi.nlm.nih.gov/pubmed/20096702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.033
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