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Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor.

We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds, acts to inhibit Escherichia coli DNA gyrase. Cyclothialidine up to 100 micrograms/ml showed no effect on DNA gyrase when linear DNA was used as a substrate. Under the same c...

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Bibliografiske detaljer
Main Authors: Nakada, N, Gmünder, H, Hirata, T, Arisawa, M
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC284669/
https://ncbi.nlm.nih.gov/pubmed/7811004
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