Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor.

We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds, acts to inhibit Escherichia coli DNA gyrase. Cyclothialidine up to 100 micrograms/ml showed no effect on DNA gyrase when linear DNA was used as a substrate. Under the same c...

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Bibliografische gegevens

Gepubliceerd in:	Antimicrob Agents Chemother
Hoofdauteurs:	Nakada, N, Gmünder, H, Hirata, T, Arisawa, M
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1994
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7811004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.9.1966
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