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Overexpression of Smoothened activates the Sonic Hedgehog signaling pathway in pancreatic cancer associated fibroblasts

PURPOSE: Accumulating evidence suggests that cancer associated stromal fibroblasts contribute to tumor growth by actively communicating with cancer cells. Our aim is to identify signaling pathways involved in tumor-stromal cell interactions in human pancreatic cancer. EXPERIMENTAL DESIGN: We establi...

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Autors principals: Walter, Kimberly, Omura, Noriyuki, Hong, Seung-Mo, Griffith, Margaret, Vincent, Audrey, Borges, Michael, Goggins, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846609/
https://ncbi.nlm.nih.gov/pubmed/20215540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1913
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