THERAPEUTIC NEUTRALIZATION OF THE NLRP1 INFLAMMASOME REDUCES THE INNATE IMMUNE RESPONSE AND IMPROVES HISTOPATHOLOGY AFTER TRAUMATIC BRAIN INJURY

Traumatic brain injury (TBI) elicits acute inflammation that in turn exacerbates primary brain damage. A crucial part of innate immunity in the immune privileged central nervous system involves production of proinflammatory cytokines mediated by inflammasome signaling. Here we show that the nucleoti...

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Bibliographic Details
Main Authors: de Rivero Vaccari, Juan Pablo, Lotocki, George, Alonso, Ofelia F., Bramlett, Helen M., Dietrich, W. Dalton, Keane, Robert W.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846547/
https://ncbi.nlm.nih.gov/pubmed/19401709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.46
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