THERAPEUTIC NEUTRALIZATION OF THE NLRP1 INFLAMMASOME REDUCES THE INNATE IMMUNE RESPONSE AND IMPROVES HISTOPATHOLOGY AFTER TRAUMATIC BRAIN INJURY

Traumatic brain injury (TBI) elicits acute inflammation that in turn exacerbates primary brain damage. A crucial part of innate immunity in the immune privileged central nervous system involves production of proinflammatory cytokines mediated by inflammasome signaling. Here we show that the nucleoti...

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Autors principals: de Rivero Vaccari, Juan Pablo, Lotocki, George, Alonso, Ofelia F., Bramlett, Helen M., Dietrich, W. Dalton, Keane, Robert W.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846547/
https://ncbi.nlm.nih.gov/pubmed/19401709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.46
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