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PGE(2) inhibition of TGF-β1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling

Myofibroblasts are pathogenic in pulmonary fibrotic disease due to their exuberant production of matrix rich in collagen that interferes with gas exchange and the ability of these cells to contract and distort the alveolar space. Transforming growth factor-β1 (TGF-β1) is a well-known inducer of myof...

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Bibliographische Detailangaben
Hauptverfasser: Thomas, Peedikayil E., Peters-Golden, Marc, White, Eric S., Thannickal, Victor J., Moore, Bethany B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846428/
https://ncbi.nlm.nih.gov/pubmed/17557799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00489.2006
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