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T-bet Down-Modulation in Tolerized Th1 Effector CD4 Cells Confers a TCR-Distal Signaling Defect That Selectively Impairs IFN-γ Expression

When Th1 effector CD4 cells encounter tolerizing Ag in vivo, their capacity to express the effector cytokines IFN-γ and TNF-α is lost more rapidly than noneffector functions such as IL-2 production and proliferation. To localize the relevant intracellular signaling defects, cytokine expression was c...

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Bibliografiske detaljer
Main Authors: Long, Meixiao, Slaiby, Aaron M., Hagymasi, Adam T., Mihalyo, Marianne A., Lichtler, Alexander C., Reiner, Steven L., Adler, Adam J.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846362/
https://ncbi.nlm.nih.gov/pubmed/16393991
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