Mast cell chymase limits the cardiac efficacy of Ang I–converting enzyme inhibitor therapy in rodents

Ang I–converting enzyme (ACE) inhibitors are widely believed to suppress the deleterious cardiac effects of Ang II by inhibiting locally generated Ang II. However, the recent demonstration that chymase, an Ang II–forming enzyme stored in mast cell granules, is present in the heart has added uncertai...

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Main Authors: Wei, Chih-Chang, Hase, Naoki, Inoue, Yukiko, Bradley, Eddie W., Yahiro, Eiji, Li, Ming, Naqvi, Nawazish, Powell, Pamela C., Shi, Ke, Takahashi, Yoshimasa, Saku, Keijiro, Urata, Hidenori, Dell’Italia, Louis J., Husain, Ahsan
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2010
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846039/
https://ncbi.nlm.nih.gov/pubmed/20335663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39345
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