Persistent Induction of Cytochrome P4501A1 in Human Hepatoma Cells by 3-Methylcholanthrene: Evidence for Sustained Transcriptional Activation of the CYP1A1 Promoter

Cytochrome P450 (P450)1A1 plays a critical role in the metabolic activation and detoxification of polycyclic aromatic hydrocarbons (PAHs), many of which are potent human carcinogens. In this investigation, we tested the hypothesis that MC elicits persistent induction of CYP1A1 expression in human he...

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Autors principals: Fazili, Inayat S., Jiang, Weiwu, Wang, Lihua, Felix, Edward A., Khatlani, Tanvir, Coumoul, Xavier, Barouki, Robert, Moorthy, Bhagavatula
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2010
Matèries:
Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846024/
https://ncbi.nlm.nih.gov/pubmed/20051482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.162222
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