PERSISTENT INDUCTION OF CYTOCHROME P450 (CYP)1A ENZYMES BY 3-METHYLCHOLANTHRENE IN VIVO IN MICE IS MEDIATED BY SUSTAINED TRANSCRIPTIONAL ACTIVATION OF THE CORRESPONDING PROMOTERS

There is significant human exposure to polycyclic aromatic hydrocarbons (PAHs), many of which are potent carcinogens. Cytochrome P450 (CYP)1A enzymes play key roles in the metabolic activation of PAHs to carcinogenic metabolites. We previously showed persistent induction of CYP1A enzymes by 3-methyl...

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Main Authors: JIANG, WEIWU, WANG, LIHUA, ZHANG, WEISHENG, COFFEE, RICHARD, FAZILI, INAYAT S., MOORTHY, BHAGAVATULA
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787915/
https://ncbi.nlm.nih.gov/pubmed/19900403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.11.021
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