Anesthetic-Induced Neurodegeneration Mediated via Inositol 1,4,5-Trisphosphate Receptors

The commonly used general anesthetic isoflurane induces widespread neurodegeneration in the developing mammalian brain through poorly understood mechanisms. We have investigated whether excessive Ca(2+) release from the endoplasmic reticulum via overactivation of inositol 1,4,5-trisphosphate recepto...

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Autori principali: Zhao, Yifan, Liang, Ge, Chen, Qianru, Joseph, Donald J., Meng, Qingcheng, Eckenhoff, Roderic G., Eckenhoff, Maryellen F., Wei, Huafeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2010
Soggetti:
Neuropharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846020/
https://ncbi.nlm.nih.gov/pubmed/20086058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.161562
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