General Anesthetics Regulate Autophagy via Modulating the Inositol 1,4,5-Trisphosphate Receptor: Implications for Dual Effects of Cytoprotection and Cytotoxicity

General anesthetics are both neuroprotective and neurotoxic with unclear mechanisms. General anesthetics may control cell survival via their effects on autophagy by activation of type 1 inositol triphosphate receptor (InsP(3)R-1). DT40 or SH-SY5Y cells with only or over 99% expression of InsP(3)R-1...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ren, Gongyi, Zhou, Yachun, Liang, Ge, Yang, Bin, Yang, Meirong, King, Alexander, Wei, Huafeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620053/
https://ncbi.nlm.nih.gov/pubmed/28959036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11607-0
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