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Pharmacological Analysis of Drosophila melanogaster γ-Secretase with Respect to Differential Proteolysis of Notch and APP
The γ-secretase aspartyl protease is responsible for the cleavage of numerous type I integral membrane proteins, including amyloid precursor protein (APP) and Notch. APP cleavage contributes to the generation of toxic amyloid β peptides in Alzheimer's disease, whereas cleavage of the Notch rece...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2845938/ https://ncbi.nlm.nih.gov/pubmed/20064975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.062471 |
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