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Pharmacological Analysis of Drosophila melanogaster γ-Secretase with Respect to Differential Proteolysis of Notch and APP

The γ-secretase aspartyl protease is responsible for the cleavage of numerous type I integral membrane proteins, including amyloid precursor protein (APP) and Notch. APP cleavage contributes to the generation of toxic amyloid β peptides in Alzheimer's disease, whereas cleavage of the Notch rece...

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Autori principali: Groth, Casper, Alvord, W. Gregory, Quiñones, Octavio A., Fortini, Mark E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845938/
https://ncbi.nlm.nih.gov/pubmed/20064975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.062471
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