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Hepatocyte Nuclear Factor 4α Regulates Rifampicin-Mediated Induction of CYP2C Genes in Primary Cultures of Human Hepatocytes

CYP2C enzymes are expressed constitutively and comprise ∼20% of the total cytochrome P450 in human liver. However, the factors influencing the transcriptional regulation of the CYP2C subfamily have only been addressed recently. In the present study, we used primary cultures of human hepatocytes to i...

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מידע ביבליוגרפי
Main Authors: Rana, Ritu, Chen, Yuping, Ferguson, Stephen S., Kissling, Grace E., Surapureddi, Sailesh, Goldstein, Joyce A.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845933/
https://ncbi.nlm.nih.gov/pubmed/20086032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.030387
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