TGF-β Inhibition Restores Terminal Osteoblast Differentiation to Suppress Myeloma Growth

BACKGROUND: Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone lesions, in which bone formation is impaired and osteoclastic bone resorption is enhanced. TGF-β, a potent inhibitor of terminal osteoblast (OB) differentiation, is abundantly deposited in...

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Hlavní autoři: Takeuchi, Kyoko, Abe, Masahiro, Hiasa, Masahiro, Oda, Asuka, Amou, Hiroe, Kido, Shinsuke, Harada, Takeshi, Tanaka, Osamu, Miki, Hirokazu, Nakamura, Shingen, Nakano, Ayako, Kagawa, Kumiko, Yata, Kenichiro, Ozaki, Shuji, Matsumoto, Toshio
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845613/
https://ncbi.nlm.nih.gov/pubmed/20360846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009870
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