Inhibition of TACE Activity Enhances the Susceptibility of Myeloma Cells to TRAIL

BACKGROUND: TNF-related apoptosis-inducing ligand/Apo2 ligand (TRAIL/Apo2L) selectively induces apoptosis in various cancer cells including myeloma (MM) cells. However, the susceptibility of MM cells to TRAIL is largely low in most of MM cells by yet largely unknown mechanisms. Because TNF-α convert...

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Autori principali: Kagawa, Kumiko, Nakano, Ayako, Miki, Hirokazu, Oda, Asuka, Amou, Hiroe, Takeuchi, Kyoko, Nakamura, Shingen, Harada, Takeshi, Fujii, Shiro, Yata, Kenichiro, Ozaki, Shuji, Matsumoto, Toshio, Abe, Masahiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289627/
https://ncbi.nlm.nih.gov/pubmed/22389670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031594
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