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Presenilins and the γ-secretase: still a complex problem
The presenilins form part of a complex of membrane proteins that are involved in the proteolytic cleavage of cell-surface molecules. This article reviews the history of the discovery of the presenilins, their role in the pathogenesis of Alzheimer's disease and in the metabolism of the amyloid-β...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2845129/ https://ncbi.nlm.nih.gov/pubmed/20181106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-3-7 |
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