Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach

The adrenomedullary hormone epinephrine transduces environmental stressors into cardiovascular events (tachycardia and hypertension). Although the epinephrine biosynthetic enzyme PNMT genetic locus displays both linkage and association to such traits, genetic variation underlying these quantitative...

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Detalhes bibliográficos
Main Authors: Rodríguez-Flores, Juan L., Zhang, Kuixing, Kang, Sun Woo, Wen, Gen, Ghosh, Sajalendu, Friese, Ryan S., Mahata, Sushil K., Subramaniam, Shankar, Hamilton, Bruce A., O’Connor, Daniel T.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844968/
https://ncbi.nlm.nih.gov/pubmed/20204374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-010-9253-y
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