CSF Concentrations of Brain Tryptophan and Kynurenines during Immune Stimulation with IFN-alpha: Relationship to CNS Immune Responses and Depression

Cytokine-induced activation of indoleamine 2,3 dioxygenase (IDO) catabolizes L-tryptophan (TRP) into L-kynurenine (KYN), which is metabolized to quinolinic acid (QUIN) and kynurenic acid (KA). QUIN and KA are neuroactive and may contribute to the behavioral changes experienced by some patients durin...

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Main Authors: Raison, Charles L., Dantzer, Robert, Kelley, Keith W., Lawson, Marcus A., Woolwine, Bobbi J., Vogt, Gerald, Spivey, James R., Saito, Kuniaki, Miller, Andrew H.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844942/
https://ncbi.nlm.nih.gov/pubmed/19918244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2009.116
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